Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 26 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 26 samples: 10 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Spatial control of m(6)A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatinMolecular cell · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE272469_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1136916 and SRA study SRP520539. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 10 replicated groups read from 26 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8403153 CRISPR_screen_high_fluorescence_intensity
- GSM8403154 CRISPR_screen_low_fluorescence_intensity
- GSM8403155 GLORI_WT_rep1 GLORI_WT
- GSM8403156 GLORI_WT_rep2 GLORI_WT
- GSM8403157 GLORI_3KR_rep1 GLORI_3KR
- GSM8403158 GLORI_3KR_rep2 GLORI_3KR
- GSM8700874 caRNAseq_WT_rep1 caRNAseq_WT
- GSM8700875 caRNAseq_WT_rep2 caRNAseq_WT
- GSM8700876 caRNAseq_WT_rep3 caRNAseq_WT
- GSM8700877 caRNAseq_3KR_rep1 caRNAseq_3KR
- GSM8700878 caRNAseq_3KR_rep2 caRNAseq_3KR
- GSM8700879 caRNAseq_3KR_rep3 caRNAseq_3KR
- GSM8700880 RNAseq_WT_rep1 RNAseq_WT
- GSM8700881 RNAseq_WT_rep2 RNAseq_WT
- GSM8700882 RNAseq_WT_rep3 RNAseq_WT
- GSM8700883 RNAseq_3KR_rep1 RNAseq_3KR
- GSM8700884 RNAseq_3KR_rep2 RNAseq_3KR
- GSM8700885 RNAseq_3KR_rep3 RNAseq_3KR
- GSM8700896 CUTTag_METTL3_WT_rep1 CUTTag_METTL3_WT
- GSM8700897 CUTTag_METTL3_WT_rep2 CUTTag_METTL3_WT
- GSM8700898 CUTTag_METTL3_3KR_rep1 CUTTag_METTL3_3KR
- GSM8700899 CUTTag_METTL3_3KR_rep2 CUTTag_METTL3_3KR
- GSM8700900 CUTTag_H3K27ac_WT_rep1 CUTTag_H3K27ac_WT
- GSM8700901 CUTTag_H3K27ac_WT_rep2 CUTTag_H3K27ac_WT
- GSM8700902 CUTTag_H3K27ac_3KR_rep1 CUTTag_H3K27ac_3KR
- GSM8700903 CUTTag_H3K27ac_3KR_rep2 CUTTag_H3K27ac_3KR
- GSE285328 Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin [RNA-seq] 6 samples shares mettl3, h3k27, co-acetylation, deposition, chromatin, enhancer, promoter, spatial
- GSE239270 Investigate FOXA2, NKX2-1, CTCF and P300 cistrome and enhancer (H3K27ac and H3k4me1) reprogramming during NEPC transformation by ChIP-seq. 104 samples shares h3k27, enhancer
- GSE312029 Spatiotemporal remodeling of chromatin topology architecture and H3K27me3 redistribution underlies vascular pathology in Hutchinson-Gilford progeria syndrome [CUT&Tag] 84 samples shares h3k27, chromatin
- GSE288140 HDAC2-Mediated Recruitment of METTL3 to Chromatin Regulates Human Embryonic Stem Cell Differentiation 74 samples shares mettl3, chromatin
- GSE275738 METTL3-dependent m6A RNA methylation represses transposable elements derived enhancers to suppress naïve pluripotency in human pluripotent stem cells 72 samples shares mettl3, enhancer
- GSE220870 METTL3 Promotes Histone H3K9 Acetylation through Recruitment of Histone Acetyltransferase 1 to Chromatin 43 samples shares mettl3, chromatin
- GSE342612 Transcriptomic and H3K27ac chromatin responses of human microglia to acute PFOS exposure and recovery 36 samples shares h3k27, chromatin
- GSE287825 The METTL3-YTHDC1 axis mediates architectural RNA m6A modification to modulate the integrity of chromatin TADs in MLLr+ AML genome 36 samples shares mettl3, chromatin
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.