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SUMOylation inhibition potentiates CAR T activity against Multiple Myeloma (scRNA-Seq)

GSE272474 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/07/18 Platform GPL24676
Summary
Chimeric antigen receptor (CAR)-T cell therapy has shown remarkable clinical efficacy against hematologic malignancies; however, tumor relapse occurs commonly due to T cell dysfunction presenting as exhaustion and loss of effector function. Here, we identified SUMOylation inhibition promoted T cell effector function and prevented T cell exhaustion. Combination of SUMO E1 inhibitor TAK-981, significantly potentiated CAR T cell anti-tumor activity and improved persistence of CAR-presenting T cells in vivo, presenting a potent novel therapeutic approach.
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Also filed as BioProject PRJNA1136945 and SRA study SRP520565. Searching any of these in the dataset finder brings you back here.

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