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High-throughput Sequencing Quantitative Analysis of altered genes expression in bladder cancer with anti-PD-1 treatment

GSE272539 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/16 Platform GPL24247
Summary
Immune-checkpoint blockade (ICB) therapy has profoundly changed the landscape of cancer treatment strategies. Despite its success, resistance remains a significant challenge, with the majority of patients exhibiting non-response to ICB therapies. ICB reinvigorates tumor-specific T cells by interrupting inhibitory signals mediated by checkpoints like PD-1 and CTLA-4, pivotal for the reactivation of their anti-tumor functions. Within the tumor microenvironment, tumor-specific T cells enter a state of dysfunction, making it difficult to generate an effective response to ICB. This study aims to investigate the altered transcriptome in anti-PD-1 responders and non-responders of bladder cancer (BCa) and to uncover the underlying mechanisms of T cell non-responses to ICB.
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Direct links to NCBI, no account and no request form: the whole study as GSE272539_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1137307 and SRA study SRP520757. Searching any of these in the dataset finder brings you back here.

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