← BioTransfer GEO Dataset Finder
GEO series

PD-L1/PD-1 checkpoint pathway regulates astrocyte morphogenesis and myelination during mouse brain development

GSE272614 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/07/18 Platform GPL17021
Summary
To gain futher insight into how astrocyte-derived PD1 regulates astrocyte morphogenesis and myelination, RNA-seq was used to analyze the genome-wide changes resulting from isolated astrocyte of P5 astrocyte-PD1 conditional knock out mice and littermate wild-type. Approximately six thousand transcripts showed differential expression between the Pd1fl/fl and Pd1cKO-Aldh1l1 mice brain astrocyte, with a fold change ≥3 and p value <0.05.Geneontology analysis of the downregulated genes were enriched in terms related to negative regulation of signal transduction, positive regulation of actin nucleation and upregulated genes were enriched in terms related to inflammatory response, positive regulation of ERK1 and ERK2 cascade and cell surface receptor signaling pathway. These results reflected astrocyte-PD1 plays roles in astrocyte development.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE272614_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1137524 and SRA study SRP520897. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.