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GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility during aging

GSE272899 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2025/10/14 Platform GPL24247
Summary
SMAD2/3 transcription factors (TFs) have low DNA binding affinity for a specific consensus sequence, allowing them to elicit anti- or pro-inflammatory responses depending on the cellular context. Genes associated with pro-inflammatory processes in immune cells, including myeloid cells, exhibit increased chromatin accessibility with age. We hypothesized that this could affect the transcriptional activity of SMAD2/3 in adipose tissue macrophages (ATMs). To assess chromatin accessibility, ATMs isolated using fluorescence-activated cell sorting (FACS) from young control, old control and old mKO mice were profiled using assay for ATAC-seq.
Published in
GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility during aging
Jang IH, Kruglov V, Cholensky SH et al. · bioRxiv : the preprint server for biology 2024 · PMID 39386655 · doi:10.1101/2024.09.23.614375
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Also filed as BioProject PRJNA1139202 and SRA study SRP521719. Searching any of these in the dataset finder brings you back here.

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