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Peripheral nerve injury induces dystonia-like movements and dysregulation in the energy metabolism: A multi-omics descriptive study in Thap1+/− mice

GSE273221 Mus musculus (mouse) Non-coding RNA profiling 144 samples Submitted 2025/01/03 Platform GPL30172
At a glance

Non-coding RNA profiling · mouse · 144 samples

What it is
Non-coding RNA profilingLevels of RNAs that do not code for proteins, such as miRNA or lncRNA.
Organism
Mus musculus (mouse)
Samples
144 samples: 24 conditions, mostly with about 6 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Peripheral nerve injury induces dystonia-like movements and dysregulation in the energy metabolism: A multi-omics descriptive study in Thap1(+/-) miceNeurobiology of disease · 2025
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
Peripheral nerve injury induces dystonia-like movements and dysregulation in the energy metabolism: A multi-omics descriptive study in Thap1(+/-) mice
Reinhold C, Knorr S, McFleder RL et al. · Neurobiology of disease 2025 · PMID 39732371 · doi:10.1016/j.nbd.2024.106783
This dataset
Open GSE273221 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE273221_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

Also filed as BioProject PRJNA1140617 and SRA study SRP522461. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 39732371) ↗
Study design
24 conditions, mostly with about 6 replicates each
cortex,wt, naive, miRNA, biol ×6 cortex, wt, nerve-injured, miRNA, biol ×6 cortex, Thap1+/-, naive, miRNA, biol ×6 cortex, Thap1+/-, nerve-injured, miRNA, biol ×6 striatum, wt, naive, miRNA, biol ×6 striatum, wt, nerve-injured, miRNA, biol ×6 striatum, Thap1+/-, naive, miRNA, biol ×6 striatum, THap1+/-, nerve-injured, miRNA, biol ×6 +16 more

Supports a between-group comparison across 144 samples.

How we read this: 24 replicated groups read from 144 sample titles; they account for 144 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 104 more — browse all 144 samples with per-sample file links →

Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.