GEO series
IgE plasma cells differentially regulate antibody secretion, ER stress and tissue-specific longevity relative to other isotypes
GSE273256
Mus musculus; Homo sapiens
Expression profiling by high throughput sequencing
18 samples
2024/11/27
GPL24247GPL24676
Summary
Understanding the transcriptional signature of IgE producing cells is fundamental to plasma cell biology. IgE PCs from bone marrow (BM) upregulated genes associated with pro-survival, and BM homing, whereas IgE PCs from draining lymph nodes (dLN) expressed genes associated with recent class-switching and differenatiation. Finally, IgE PCs exhibited higher expression of ER stress and protein coding compared to IgG1.
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Paper (PMID 39241058) ↗
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