GEO series
Effects of hyperbaric oxygen on tissue-specific aging and senescence in mice and human stromal cells
GSE296209
Mus musculus; Homo sapiens
Expression profiling by high throughput sequencing
45 samples
2025/05/09
GPL34290GPL24676
Summary
This study investigates the effects of hyperbaric oxygen (HBO) on cellular senescence and aging-related phenotypes. In naturally aged mice, HBO treatment reduced systemic senescence burden and reversed aging-related transcriptomic signatures in skin, liver, and kidney tissues. Additionally, single-session HBO exposure was shown to preferentially suppress SASP propagation in human stromal cells. This dataset includes transcriptomic profiles of skin, liver, and kidney tissues from young, aged, and HBO-treated aged mice, as well as human primary prostate stromal cells (PSC27).
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