Specific requirement of the p84/p110γ complex of PI3Kγ for antibody-activated, inducible cross-presentation in murine type 2 DCs
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × DC1, WT, steady state, vs 3 × DC2, WT, steady state, vs 3 × DC2, p101KO, steady state, vs 3 × DC2, p84KO, steady state,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody-Activated, Inducible Cross-Presentation in Murine Type 2 DCsAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE273544_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1142077 and SRA study SRP523242. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8432058 DC1, WT, steady state, rep1 DC1, WT, steady state,
- GSM8432059 DC1, WT, steady state, rep2 DC1, WT, steady state,
- GSM8432060 DC1, WT, steady state, rep3 DC1, WT, steady state,
- GSM8432061 DC2, WT, steady state, rep1 DC2, WT, steady state,
- GSM8432062 DC2, WT, steady state, rep2 DC2, WT, steady state,
- GSM8432063 DC2, WT, steady state, rep3 DC2, WT, steady state,
- GSM8432064 DC2, p101KO, steady state, rep1 DC2, p101KO, steady sta…
- GSM8432065 DC2, p101KO, steady state, rep2 DC2, p101KO, steady sta…
- GSM8432066 DC2, p101KO, steady state, rep3 DC2, p101KO, steady sta…
- GSM8432067 DC2, p84KO, steady state, rep1 DC2, p84KO, steady stat…
- GSM8432068 DC2, p84KO, steady state, rep2 DC2, p84KO, steady stat…
- GSM8432069 DC2, p84KO, steady state, rep3 DC2, p84KO, steady stat…
- GSE234578 PI3K/AKT signalling regulates mouse Inner Cell Mass (ICM) progenitor specification [scRNA-seq] 186 samples shares pi3k, specific
- GSE290680 Nuclear class 3 PI3K co-activates fasting-specific chromatin remodeling 36 samples shares pi3k, specific
- GSE265767 PI3K/AKT signalling regulates mouse Inner Cell Mass (ICM) progenitor specification [FLASH-seq] 26 samples shares pi3k, specific
- GSE320350 Nuclear class 3 PI3K co-activates fasting-specific chromatin remodeling 12 samples shares pi3k, specific
- GSE290681 Nuclear class 3 PI3K co-activates fasting-specific chromatin remodeling 17 samples shares pi3k, specific
- GSE302836 Loss of Hepatocyte PI3Ka Protects Mice from Hepatocellular Carcinoma in association with altered lipid metabolism gene expression 42 samples shares pi3k
- GSE277881 Hyperactive PI3K-delta in Th1 and Th2 differentiation [RNA-seq] 42 samples shares pi3k
- GSE69104 A paracrine IGF1/IGF1R-PI3K signaling loop underlies resistance to CSF-1R inhibition in GBM 32 samples shares pi3k
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.