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Evaluation of bovine colostrum extracellular vesicles on NASH mouse model

GSE273582 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/08/01 Platform GPL24247
Summary
The potential of orally administered colostrum-derived EVs to regulate gut microbiota dysbiosis and prevent non-alcoholic steatohepatitis was evaluated. The results demonstrated that colostrum-derived EVs improved steatosis, fibrosis, and inflammation. Transcriptome analysis showed decreased lipid metabolism, bacterial response, and inflammatory responses in the intestine, and reduced inflammatory and fibrosis-related pathways in the liver. Gut microbiota and metabolite analysis revealed an increased abundance of Akkermansia and elevated cholesterol excretion. Additionally, treatment with colostrum-derived EVs increased the production of tight junction proteins and mucin in the intestine. These findings suggest that increased Akkermansia due to colostrum-derived EVs improves intestinal inflammation and barrier function, preventing endotoxin translocation to the liver and thereby reducing liver inflammation and fibrosis.
Published in
Bovine colostrum-derived extracellular vesicles protect against non-alcoholic steatohepatitis by modulating gut microbiota and enhancing gut barrier function
Mun D, Ryu S, Lee DJ et al. · Current research in food science 2025 · PMID 40231313 · doi:10.1016/j.crfs.2025.101039
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Also filed as BioProject PRJNA1142463 and SRA study SRP523352. Searching any of these in the dataset finder brings you back here.

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