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NEDDylation modifies mitochondrial transcription to maintain oocyte quality (Oocyte)

GSE273770 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/01 Platform GPL24247
Summary
Aging decreases oocyte quality, leading to infertility, miscarriage, and birth defects. Major contributors to this decline include mitochondrial dysfunction and chromosome dynamics dysregulation. Here, we show that oocyte-specific deletion of Uba3, which encodes the catalytic subunit of the E1 NEDDylation activating complex (NAE), in mice causes sterility and premature depletion of the ovarian reserve. Fully grown Uba3 conditional knockout oocytes show hallmarks of mitochondrial abnormalities, including increased reactive oxygen species, decreased oxidative phosphorylation, and increased unhealthy mitochondria. These discoveries provide insight into mechanisms governing oocyte quality and a regulatory role of NEDDylation for mitochondrial transcription in gametes.
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Also filed as BioProject PRJNA1143033 and SRA study SRP523721. Searching any of these in the dataset finder brings you back here.

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