Nuclear receptor Nur77 resolves the inflammatory response of macrophages primarily by cis- and trans-regulation of AP-1 target genes [ChIP-Seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 26 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 26 samples: 10 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE273993_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1144425 and SRA study SRP524427. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 22 samples.
How we read this: 10 replicated groups read from 26 sample titles; they account for 22 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8441203 Nur77_HA_Ctrl1 Nur77_HA_Ctrl
- GSM8441204 Nur77_HA_Ctrl2 Nur77_HA_Ctrl
- GSM8441205 Nur77_HA_Ctrl3 Nur77_HA_Ctrl
- GSM8441206 Nur77_HA_LPS1 Nur77_HA_LPS
- GSM8441207 Nur77_HA_LPS2 Nur77_HA_LPS
- GSM8441208 Nur77_HA_LPS3 Nur77_HA_LPS
- GSM8441209 GFP_RNApol_Ctrl1 GFP_RNApol_Ctrl
- GSM8441210 GFP_RNApol_Ctrl2 GFP_RNApol_Ctrl
- GSM8441211 GFP_RNApol_LPS1 GFP_RNApol_LPS
- GSM8441212 GFP_RNApol_LPS2 GFP_RNApol_LPS
- GSM8441213 Nur77_RNApol_Ctrl1 Nur77_RNApol_Ctrl
- GSM8441214 Nur77_RNApol_Ctrl2 Nur77_RNApol_Ctrl
- GSM8441215 Nur77_RNApol_LPS1 Nur77_RNApol_LPS
- GSM8441216 Nur77_RNApol_LPS2 Nur77_RNApol_LPS
- GSM8441217 GFP_H3K27ac_Ctrl1 GFP_H3K27ac_Ctrl
- GSM8441218 GFP_H3K27ac_Ctrl2 GFP_H3K27ac_Ctrl
- GSM8441219 GFP_H3K27ac_LPS1 GFP_H3K27ac_LPS
- GSM8441220 GFP_H3K27ac_LPS2 GFP_H3K27ac_LPS
- GSM8441221 Nur77_H3K27ac_Ctrl1 Nur77_H3K27ac_Ctrl
- GSM8441222 Nur77_H3K27ac_Ctrl2 Nur77_H3K27ac_Ctrl
- GSM8441223 Nur77_H3K27ac_LPS1 Nur77_H3K27ac_LPS
- GSM8441224 Nur77_H3K27ac_LPS2 Nur77_H3K27ac_LPS
- GSM8441225 GFP_input_Ctrl
- GSM8441226 GFP_input_LPS
- GSM8441227 Nur77_input_Ctrl
- GSM8441228 Nur77_input_LPS
- GSE326173 Nuclear receptor Nur77 resolves the inflammatory response of macrophages primarily by regulating expression of AP-1 transcription factors and their target genes [ChIP-seq] 42 samples shares nur77, ap-1, macrophages, primarily, receptor, resolves, chip-seq
- GSE325918 Nuclear receptor Nur77 resolves the inflammatory response of macrophages primarily by regulating expression of AP-1 transcription factors and their target genes [RNA-seq] 32 samples shares nur77, ap-1, macrophages, primarily, receptor, resolves
- GSE250551 Targeting inflammation with chimeric antigen receptor macrophages using a signal switch 32 samples shares macrophages, receptor
- GSE272424 Rejuvenating endogenous antitumor immunity via a chimeric receptor-engineered oncolytic virus targeting tumor-associated macrophages 6 samples shares macrophages, receptor
- GSE223050 The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1–linked chromatin opening 336 samples shares ap-1
- GSE310740 Modulating AP-1 enables CAR-T cells to establish an intratumoral stem-like reservoir and overcomes resistance to PD-1 blockade 16 samples shares ap-1
- GSE202753 DsbA-L deficiency attenuates LPS-induced acute kidney injury via NF-κB/AP-1 regulation of macrophage polarization 13 samples shares ap-1
- GSE269844 Dissecting AP-1 complexity in hepatic health and disease using Genetically Modified Mice 12 samples shares ap-1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.