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Characterization of differential gene expression pattern in control and microglia depleted retinas during retinal vascular development in mice

GSE274107 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/02/26 Platform GPL30172
Summary
This study reports the comprehensive gene expression profiling of postnatal day (P) 10 control diet (Control) and Csf1r antagonist (PLX5622, Plexicon Inc. Berkeley, CA) diet fed microglia deplted retinas (referred as PLX5622) during development. Further functional enrichment analysis revealed down-regulation of biological processes linked to phagocytosis and innate immune signaling.
Published in
Microglial depletion decreases Müller cell maturation and inner retinal vascular density
Rowthorn-Apel N, Vridhachalam N, Connor KM et al. · Cell communication and signaling : CCS 2025 · PMID 39962511 · doi:10.1186/s12964-025-02083-5
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Direct links to NCBI, no account and no request form: the whole study as GSE274107_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1144968 and SRA study SRP524516. Searching any of these in the dataset finder brings you back here.

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