Precise modulation of mSWI/SNF identified dosage-sensitive chromatin regulation [RNA-Seq]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Precise modulation of BRG1 levels reveals features of mSWI/SNF dosage sensitivityNature genetics · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE274356_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1146038 and SRA study SRP525135. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8447836 Control RNA-seq rep1 Control RNA-seq
- GSM8447837 Control RNA-seq rep2 Control RNA-seq
- GSM8447838 0.3n dTag RNA-seq rep1 0.3n dTag RNA-seq
- GSM8447839 0.3n dTag RNA-seq rep2 0.3n dTag RNA-seq
- GSM8447840 1n dTag RNA-seq rep1 1n dTag RNA-seq
- GSM8447841 1n dTag RNA-seq rep2 1n dTag RNA-seq
- GSM8447842 3n dTag RNA-seq rep1 3n dTag RNA-seq
- GSM8447843 3n dTag RNA-seq rep2 3n dTag RNA-seq
- GSM8447844 10n dTag RNA-seq rep1 10n dTag RNA-seq
- GSM8447845 10n dTag RNA-seq rep2 10n dTag RNA-seq
- GSM8447846 100n dTag RNA-seq rep1 100n dTag RNA-seq
- GSM8447847 100n dTag RNA-seq rep2 100n dTag RNA-seq
- GSE274357 Precise modulation of mSWI/SNF identified dosage-sensitive chromatin regulation [ATAC-Seq] 14 samples shares snf, dosage-sensitive, modulation, identified, chromatin, precise, mswi
- GSE272547 EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling [RNA-Seq] 49 samples shares snf, rna-seq
- GSE248369 The Swi/Snf chromatin remodeling complex regulates pancreatic endocrine cell expansion and differentiation in vivo 10 samples shares snf, chromatin
- GSE226954 SWI/SNF-dependent genes are defined by their chromatin landscape 61 samples shares snf, chromatin
- GSE268206 CRISPR screen decodes SWI/SNF chromatin remodeling complex assembly 56 samples shares snf, chromatin
- GSE242799 Effect of SWI/SNF pertubations on chromatin accessibility during macrophage inflammatory activation [ATAC-seq] 40 samples shares snf, chromatin
- GSE249211 SWI/SNF-dependent genes are defined by their chromatin landscape [ChIP-seq_2] 24 samples shares snf, chromatin
- GSE303699 Autoimmune Disease Risk Gene ANKRD55 Promotes Th17 Effector Function Through Metabolic Modulation [RNA-Seq] 60 samples shares modulation, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.