Precise modulation of mSWI/SNF identified dosage-sensitive chromatin regulation [ATAC-Seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 14 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 7 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Precise modulation of BRG1 levels reveals features of mSWI/SNF dosage sensitivityNature genetics · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE274357_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1146037 and SRA study SRP525139. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 7 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8447848 WT ATAC rep1 WT ATAC
- GSM8447849 WT ATAC rep2 WT ATAC
- GSM8447850 Control ATAC rep1 Control ATAC
- GSM8447851 Control ATAC rep2 Control ATAC
- GSM8447852 0.3n dTag ATAC rep1 0.3n dTag ATAC
- GSM8447853 0.3n dTag ATAC rep2 0.3n dTag ATAC
- GSM8447854 1n dTag ATAC rep1 1n dTag ATAC
- GSM8447855 1n dTag ATAC rep2 1n dTag ATAC
- GSM8447856 3n dTag ATAC rep1 3n dTag ATAC
- GSM8447857 3n dTag ATAC rep2 3n dTag ATAC
- GSM8447858 10n dTag ATAC rep1 10n dTag ATAC
- GSM8447859 10n dTag ATAC rep2 10n dTag ATAC
- GSM8447860 100n dTag ATAC rep1 100n dTag ATAC
- GSM8447861 100n dTag ATAC rep2 100n dTag ATAC
- GSE274356 Precise modulation of mSWI/SNF identified dosage-sensitive chromatin regulation [RNA-Seq] 12 samples shares snf, dosage-sensitive, modulation, identified, chromatin, precise, mswi
- GSE242799 Effect of SWI/SNF pertubations on chromatin accessibility during macrophage inflammatory activation [ATAC-seq] 40 samples shares snf, chromatin, atac-seq
- GSE272545 EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling [ATAC-Seq] 30 samples shares snf, atac-seq
- GSE249211 SWI/SNF-dependent genes are defined by their chromatin landscape [ChIP-seq_2] 24 samples shares snf, chromatin
- GSE226954 SWI/SNF-dependent genes are defined by their chromatin landscape 61 samples shares snf, chromatin
- GSE268206 CRISPR screen decodes SWI/SNF chromatin remodeling complex assembly 56 samples shares snf, chromatin
- GSE248369 The Swi/Snf chromatin remodeling complex regulates pancreatic endocrine cell expansion and differentiation in vivo 10 samples shares snf, chromatin
- GSE288332 Neuronal type-specific modulation of cognition and AP-1 signaling by early-life rearing conditions. [ATAC-Seq] 18 samples shares modulation, atac-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.