GEO series
TICRR/TRESLIN and MTBP Cut&Run in Asynchronously Cycling HCT116 Cells
GSE274463
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
27 samples
2025/05/27
GPL24676
Summary
The selection of replication origins plays a crucial role in eukaryotic DNA replication. However, the mechanisms of origin selection in humans are not yet well-defined. Recent work in yeast has shown that the recruitment of Sld3-Sld7 to origins during G1 is involved in origin selection. In humans, TICRR/TRESLIN and MTBP are the orthologs of Sld3 and Sld7, respectively. In this study, we have mapped the genomic binding locations of TICRR/TRESLIN and MTBP in asynchronous cells.
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Paper (PMID 40624716) ↗
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