GEO series
TICRR/TRESLIN and MTBP Cut&Run in HCT116 cells with inhibited origin licensing
GSE274465
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
12 samples
2025/05/27
GPL24676
Summary
The selection of replication origins plays a crucial role in eukaryotic DNA replication. However, the mechanisms of origin selection in humans still need to be defined. Recent work in yeast has shown that the recruitment of Sld3-Sld7 to origins during G1 is involved in origin selection. In humans, TICRR/TRESLIN and MTBP are the orthologs of Sld3 and Sld7, respectively. In this study, we have mapped the genomic binding locations of TICRR/TRESLIN and MTBP in cells where loading of MCM2-7 complex has been inhibited by dox-inducible expression of a degradation-resistant Geminin(T25D).
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Paper (PMID 40624716) ↗
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