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Effect of Sorafenib on Myeloid-derived suppressor cells in HCC

GSE274470 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/05 Platform GPL21103
Summary
Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related deaths worldwide. Sorafenib, a multikinase inhibitor, is the first-line systemic therapy approved for advanced HCC, but its impact on the tumor microenvironment, particularly on myeloid-derived suppressor cells (MDSCs), is not fully understood.MDSCs are a heterogeneous population of immune cells that play a crucial role in promoting tumor growth and immune evasion by suppressing T cell function and facilitating an immunosuppressive microenvironment. This study investigates the effects of sorafenib on the function and phenotype of MDSCs in HCC.
Published in
Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation
Li C, Xiong L, Yang Y et al. · Molecular cancer 2025 · PMID 39876004 · doi:10.1186/s12943-025-02238-5
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Also filed as BioProject PRJNA1146471 and SRA study SRP525433. Searching any of these in the dataset finder brings you back here.

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