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RNA-sequencing of testes from control and Hormad1&2SFB/SFB mice

GSE274491 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/12 Platform GPL24247
Summary
To examine whether Hormad1&2SFB/SFB (dsfb) male mice has defect in the meiotic sex chromosome inactivation (MSCI) process or not, three pairs of P19 testes were collected from each strain and mRNA-sequencing was performed. The data revealed that the transcription of X and Y chromosomes, but not autosomes, were specifically elevated. Therefore, MSCI was defective in dsfb spermatocytes.
Published in
Aberrant activation of chromosome asynapsis checkpoint triggers oocyte elimination
Jiao X, Liang Z, Li J et al. · Nature communications 2025 · PMID 40050306 · doi:10.1038/s41467-025-57702-z
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Also filed as BioProject PRJNA1146735 and SRA study SRP525588. Searching any of these in the dataset finder brings you back here.

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