← BioTransfer GEO Dataset Finder
GEO series

snRNA-seq of murine tarsal plates

GSE274498 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/01/21 Platform GPL24247
Summary
The eyelid is a complex environment containing, containing epidermal, hair follicles, and conjunctival cells closely adjacent to the Meibomian glands (MGs), making it challenging to isolate pure MG cells or to identify MG contributions in bulk RNA-seq analyses. To analyze transcription in MG subpopulations, and to overcome difficulties in isolating cytoplasmic mRNAs from lipid-rich acinar cells, we utilized snRNA-seq which allows for identification of cell sub-populations within a complex mix.
Published in
Identification of Meibomian gland stem cell populations and mechanisms of aging
Zhu X, Xu M, Portal C et al. · Nature communications 2025 · PMID 39955307 · doi:10.1038/s41467-025-56907-6
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE274498_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1146742 and SRA study SRP525596. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.