ZMAT1 promotes osteoclast formation and bone loss through TRIM46 mediated YAP1 degradation.
RNA-seq (gene expression) · mouse · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits OsteoblastogenesisAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE274540_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1147172 and SRA study SRP526528. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 5 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8451004 BMDM,Control_1 BMDM,Control
- GSM8451005 BMDM,Control_2 BMDM,Control
- GSM8451006 BMDM,Control_3 BMDM,Control
- GSM8451007 BMDM,LPS_3d_1 BMDM,LPS_3d
- GSM8451008 BMDM,LPS_3d_2 BMDM,LPS_3d
- GSM8451009 BMDM,LPS_3d_3 BMDM,LPS_3d
- GSM8451010 BMDM,LPS_4h_1 BMDM,LPS_4h
- GSM8451011 BMDM,LPS_4h_2 BMDM,LPS_4h
- GSM8451012 BMDM,LPS_4h_3 BMDM,LPS_4h
- GSM8451013 BMDM,RANKL_3d_1 BMDM,RANKL_3d
- GSM8451014 BMDM,RANKL_3d_2 BMDM,RANKL_3d
- GSM8451015 BMDM,RANKL_3d_3 BMDM,RANKL_3d
- GSM8451016 BMDM,RANKL_4h_1 BMDM,RANKL_4h
- GSM8451017 BMDM,RANKL_4h_2 BMDM,RANKL_4h
- GSM8451018 BMDM,RANKL_4h_3 BMDM,RANKL_4h
- GSE274930 ZMAT1 promotes osteoclast formation and bone loss through TRIM46 mediated YAP1 degradation II 18 samples shares trim46, zmat1, yap1, degradation, osteoclast, formation, promotes, mediated
- GSE274533 ZMAT1 promotes osteoclast formation and bone loss through TRIM46 mediated YAP1 degradation. [CUT&Tag] 2 samples shares trim46, zmat1, yap1, degradation, osteoclast, formation, promotes, mediated
- GSE269006 YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells [RNA-seq] 15 samples shares yap1, formation, mediated
- GSE269007 YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells 27 samples shares yap1, formation, mediated
- GSE269004 YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells [ATAC-seq] 12 samples shares yap1, formation, mediated
- GSE293160 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced gene [RNA-seq] 24 samples shares degradation, mediated
- GSE263260 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced genes : Gene expression 1 12 samples shares degradation, mediated
- GSE263261 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced genes : Gene expression 2 8 samples shares degradation, mediated
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.