G3BP1 translocates into mitochondria to impair MCU complex function and promotes NASH progression [G3bp1-HKO and G3bp1-Flox mice with BSA or PA treatment]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE274650_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1147585 and SRA study SRP526011. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8454149 primary hepatocytes, Flox-1,BSA
- GSM8454150 primary hepatocytes, Flox-2,BSA
- GSM8454151 primary hepatocytes, Flox-3, BSA
- GSM8454152 primary hepatocytes, HKO-1,BSA
- GSM8454153 primary hepatocytes, HKO-2, BSA
- GSM8454154 primary hepatocytes, HKO-3, BSA
- GSM8454155 primary hepatocytes, Flox-1, PA
- GSM8454156 primary hepatocytes, Flox-2, PA
- GSM8454157 primary hepatocytes, Flox-3, PA
- GSM8454158 primary hepatocytes, HKO-1, PA
- GSM8454159 primary hepatocytes, HKO-2, PA
- GSM8454160 primary hepatocytes, HKO-3, PA
- GSE218073 Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis [LKO_NASH] 10 samples shares nash, mitochondria
- GSE256063 Zalfermin and semaglutide have beneficial effects liver histology and fibrotic gene in a murine model of NASH 56 samples shares nash
- GSE255356 A 5:2 intermittent fasting regimen initiated in the active phase ameliorates NASH, fibrosis and blunts HCC development via hepatic PPARα and PCK1 39 samples shares nash
- GSE256502 Sex differences in Non-Alcoholic Steatohepatitis (NASH) in mice evoked by a fructose-palmitate-cholesterol (FPC)-enriched diet [bulk_isolated_cells] 31 samples shares nash
- GSE240047 A Metabolic Switch Controlling Liver Cancer Evolution from Senescent NASH Hepatocytes 30 samples shares nash
- GSE255799 Charaterization of potential roles and mechanisms of ACBP/DBI in NASH/MASH-dirven HCC mouse models 27 samples shares nash
- GSE241855 NASH time course 25 samples shares nash
- GSE205846 Hepatocyte FBXW7-dependent activity of nutrient-sensing nuclear receptors controls systemic energy homeostasis and NASH progression [RNA-Seq] 16 samples shares nash
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.