Knockdown of PPARγ can ameliorate benzbromarone-induced obesity-specific drug-induced liver injury
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 5 × C vs 5 × BB vs 5 × P vs 5 × PBBGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Slow Metabolism-Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone-Induced Obesity-Specific Liver InjuryAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE274748_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1147752 and SRA study SRP526129. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 4 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8457331 C1 C
- GSM8457332 C2 C
- GSM8457333 C3 C
- GSM8457334 C4 C
- GSM8457335 C5 C
- GSM8457336 BBR1 BB
- GSM8457337 BBR2 BB
- GSM8457338 BBR3 BB
- GSM8457339 BBR4 BB
- GSM8457340 BBR5 BB
- GSM8457341 P1 P
- GSM8457342 P2 P
- GSM8457343 P3 P
- GSM8457344 P4 P
- GSM8457345 P5 P
- GSM8457346 PBBR1 PBB
- GSM8457347 PBBR2 PBB
- GSM8457348 PBBR3 PBB
- GSM8457349 PBBR4 PBB
- GSM8457350 PBBR5 PBB
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- GSE282998 Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse livers 192 samples shares ppar, liver
- GSE319608 Enhanced antisense oligonucleotide delivery reveals that transcript turnover impacts apparent splicing rescue in myotonic dystrophy 98 samples shares ppar, liver
- GSE255356 A 5:2 intermittent fasting regimen initiated in the active phase ameliorates NASH, fibrosis and blunts HCC development via hepatic PPARα and PCK1 39 samples shares ppar, ameliorate
- GSE290187 Transcriptional profiling of bulk liver tissue from male and female PPARa knockout mice and mice expressing a human PPARa transgene following treatment with PFOA or vehicle drinking water in conjunction with an American diet 20 samples shares ppar, liver
- GSE304787 Therapeutic targeting of lipidated amino acid deficiency ameliorates MASH via a PPARα/CCL2 axis 14 samples shares ppar, ameliorate
- GSE238201 Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) [RNA-seq] 12 samples shares ppar, liver
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.