transcriptomic analysis of murine chronic proximal thoracic aortic aneurysms
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 7 × cPTAA vs 5 × NCGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Establishment of a murine chronic proximal thoracic aortic aneurysm model by combining periaortic elastase application with oral BAPN administrationEuropean journal of pharmacology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE275166_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1149746 and SRA study SRP527561. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8472273 cPTAA2 cPTAA
- GSM8472274 cPTAA3 cPTAA
- GSM8472275 cPTAA4 cPTAA
- GSM8472276 cPTAA6 cPTAA
- GSM8472277 cPTAA7 cPTAA
- GSM8472278 cPTAA9 cPTAA
- GSM8472279 cPTAA12 cPTAA
- GSM8472280 NC1 NC
- GSM8472281 NC5 NC
- GSM8472282 NC8 NC
- GSM8472283 NC10 NC
- GSM8472284 NC11 NC
- GSE333518 Growth arrest of thoracic aortic aneurysms in aging Marfan mice 8 samples shares aneurysms, thoracic, aortic
- GSE292885 Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and Rejuvenation 210 samples shares chronic
- GSE254360 Single-nucleus transcriptomic analysis of the amygdala of mice in acute and chronic neuropathic pain 15 samples shares chronic
- GSE331524 Transcriptomic analysis of hippocampus and prefrontal cortex in a mouse model of chronic radiation-induced gastrointestinal injury 12 samples shares chronic
- GSE318367 Transcriptomic analysis of colchicine effects in adenine-induced chronic kidney disease 12 samples shares chronic
- GSE250389 Transcriptomic analyses of mouse livers from an 18-month oral carcinogenicity study of HFPO-DA with a 9-month chronic toxicity phase 92 samples shares chronic
- GSE314324 Transcriptomic responses to acute or chronic ethanol exposure observed across five brain regions in male mice 62 samples shares chronic
- GSE327003 Hepatic transcriptomic changes with subchronic exposure to a dioxin mixture 48 samples shares chronic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.