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Multicellular derived S100A8/A9 maintains megakaryocytes in an immature state in immune thrombocytopenia.

GSE275370 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2026/05/15 Platform GPL18573Platform GPL19057
Summary
Immune thrombocytopenia (ITP) is a common acquired autoimmune bleeding disorder characterized by reduced platelet count. Impaired maturation of megakaryocyte (MK) plays an important role, although the exact mechanisms are not fully understood. In this study, we performed 10x Genomics single-cell sequencing (SC-seq) on bone marrow samples from ITP patients and validated the data through in vitro models of megakaryocyte generation.
Published in
CSF1R modulates megakaryopoiesis by targeting RUNX1 in immune thrombocytopenia
Han H, Zhou M, Qi J et al. · Haematologica 2026 · PMID 41414965 · doi:10.3324/haematol.2025.288511
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Direct links to NCBI, no account and no request form: the whole study as GSE275370_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1150558 and SRA study SRP527824. Searching any of these in the dataset finder brings you back here.

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