Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Tau]
RNA-seq (gene expression) · mouse · 29 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 29 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathyScience translational medicine · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE275386_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1150582 and SRA study SRP527856. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 29 more — browse all 29 samples with per-sample file links →
- GSE273541 Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [Tdt Tomato - mice] 16 samples shares ameliorates, amyloidosis, modulates, microglia, tauopathy, inhaled, xenon
- GSE254104 Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model [snRNAseq] 27 samples shares microglia, tauopathy
- GSE98969 Single cell RNA-seq identifies a unique microglia type associated with Alzheimer’s disease [RNA] 97 samples shares microglia
- GSE327428 GPR34 regulation of disease-associated microglial states in mice 96 samples shares microglia
- GSE246617 Cerebral vascular transcriptome profiling reveals intermittent fasting modulates chronic cerebral hypoperfusion-induced disease pathways. 78 samples shares modulates
- GSE223424 Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease 57 samples shares microglia
- GSE273690 Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer’s disease 48 samples shares microglia
- GSE305628 Isobavachalcone ameliorates TNBS-induced Crohn’s disease-like colitis via GPR84-PI3K-AKT axis 18 samples shares ameliorates
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.