GEO series
The role of fatty acid metabolism on Th9 cells differentiation
GSE275438
Mus musculus
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
56 samples
2024/09/10
GPL19057
Summary
T helper 9 cells (Th9) are interleukin 9 (IL-9)–producing cells that have diverse functions ranging from anti-tumor immune responses to driving allergic inflammation. Th9 cells differentiate from naïve CD4+ T cells in the presence of IL-4 and transforming growth factor-beta (TGF-β). In this reports, we have found that suppression of fatty acid biosynthesis increased IL-9 production in murine and human Th9 cells. This dataset include a set of data showing the effects of suppression of fatty acid synthesis on gene expression, chromatin remodelling and histone modifications in Th9 cells as analyzed by RNA-seq, ATAC-seq and ChIP-seq, respectively.
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Paper (PMID 39187636) ↗
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