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Altered Cell Clusters and Upregulated Aqp1 in Connexin 50 Knockout Lens Epithemium

GSE275886 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2025/09/05 Platform GPL21103
Summary
To characterize the heterogeneity and cell clusters of postnatal lens epithelial cellsLens epithelial cells exhibit an intrinsic heterogeneity of different cell clusters in regulating lens homeostasis and lens growth. Upregulated Aqp1 in Cx50KO lens epithelial cells suggests that both connexin 50 and AQP1 likely play important roles in regulating water homeostasis in lens epithelial cells. (LECs) and to investigate the downstream targets of connexin 50 (Cx50) in the regulation of lens homeostasis and lens growth. To determine differentially expressed genes (DEGs) in the connexin 50 knockout (Cx50KO) lens epithelial cells that shed light on novel mechanism underlying the cataract and small size of the Cx50KO lenses.
Published in
Altered Cell Clusters and Upregulated Aqp1 in Connexin 50 Knockout Lens Epithelium
Xia CH, Lin W, Li R et al. · Investigative ophthalmology & visual science 2024 · PMID 39287589 · doi:10.1167/iovs.65.11.27
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Also filed as BioProject PRJNA1153492 and SRA study SRP529170. Searching any of these in the dataset finder brings you back here.

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