GEO series
H4K16 acylations fine-tune transcriptional response during metabolic perturbations (ChIP-seq)
GSE275933
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
46 samples
2025/12/01
GPL21103
Summary
We studied the combined effects of the H4K16 acylations in vivo using a mouse model of the metabolic disorder propionic acidemia (PA), which causes metabolic challenges and systemic shifts in acyl-CoA ratios. Our findings indicate that H4K16 acylations modulate transcriptional responses in a concerted manner, providing insights into an adaptive chromatin regulation in response to metabolic stress.
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Paper (PMID 41421336) ↗
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