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Transcriptomic analysis of liver lymphatic endothelial cell (LyEC) isolated from sham or bile duct ligation (BDL)-induced cholestasis mouse model

GSE276093 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/12/31 Platform GPL24247
Summary
This experiment aims to determine the transcriptomic alteration in liver lympahtic endothelial cell (LyEC) in response to bile duct ligation (BDL)-induced cholestatic injury, which known to produce severe form of fibrosis and cirrhosis. We uncover a transcriptomic changes in LyEC associated with early-stage fibrosis/cirrhosis and late-stage decompensated liver cirrhosis. This work determines the functional change in lymphatic vessels and provides background necessary to discover therapeutic targets for improving LyEC function in the progression of liver diseases.
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Direct links to NCBI, no account and no request form: the whole study as GSE276093_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1154673 and SRA study SRP529699. Searching any of these in the dataset finder brings you back here.

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