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RNA sequencing analysis of doxorubicin-treated mice after administration with Akkermansia muciniphila

GSE276172 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/05/30 Platform GPL34290
Summary
Doxorubicin (DOX) is considered as the major culprit in chemotherapy-induced cardiotoxicity, which limits its clinical application. Akkermansia muciniphila (AKK) shows a beneficial role as a probiotic in the treatment of metabolic syndrome. However, the changes of AKK during DIC and whether it mediates cardioprotective effects remains unclear. Cardiac transcriptomics certified by in vitro experiments demonstrated that AKK administration effectively improved mitochondrial function and alleviated DIC, by activation of PPARα/PGC1α signaling pathway. These findings provide a therapeutic strategy for DIC through supplementation with AKK.
Published in
Akkermansia muciniphila ameliorates doxorubicin-induced cardiotoxicity by regulating PPARα-dependent mitochondrial biogenesis
Lin H, Shao X, Gu H et al. · NPJ biofilms and microbiomes 2025 · PMID 40410194 · doi:10.1038/s41522-025-00712-y
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Also filed as BioProject PRJNA1155621 and SRA study SRP530022. Searching any of these in the dataset finder brings you back here.

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