GEO series
Molecular mechanisms of the Xiao-chai-hu-tang on chronic stress-induced colorectal cancer growth based on an integrated network pharmacology and RNA sequencing approach with experimental validation
GSE276601
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2024/09/11
GPL23479
Summary
XCHT significantly inhibited CRC growth under chronic stress in a dose-dependent manner. Mechanistically, XCHT suppressed the expression levels of glycolysis associated enzymes and inflammatory factors caused by chronic stress. Moreover, XCHT significantly mitigated the activity of the JAK2/STAT3 signaling which was activated by chronic stress induced IL-6.
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Paper (PMID 40221743) ↗
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