MicroRNA-150 controls experimental autoimmune encephalomyelitis by regulating CD4 T cell differentiation and function
RNA-seq (gene expression) · mouse · 69 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 69 samples: 9 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE227937_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA947534 and SRA study SRP308487. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 43 samples.
How we read this: 9 replicated groups read from 69 sample titles; they account for 43 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM5114168 P15216_201_wt_Naive
- GSM5114169 P15216_202_wt_D7
- GSM5114170 P15216_203_ko_Naive
- GSM5114171 P15216_204_ko_D7
- GSM5114172 P15216_205_wt_Naive
- GSM5114173 P15216_206_wt_D7
- GSM5114174 P15216_207_ki_Naive
- GSM5114175 P15216_208_ki_D7
- GSM5114176 P15216_209_wt_Naive
- GSM5114177 P15216_210_wt_D7
- GSM5114178 P15216_211_ko_Naive
- GSM5114179 P15216_212_ko_D7
- GSM5114180 P15216_213_wt_Naive
- GSM5114181 P15216_214_wt_D7
- GSM5114182 P15216_215_ki_Naive
- GSM5114183 P15216_216_ki_D7
- GSM5114184 P15216_217_ki_D7
- GSM5114185 P15216_218_ko_Naive
- GSM5114186 P15216_219_ko_D7
- GSM5114187 P15216_220_ki_Naive
- GSM5114188 P15216_221_ki_D7
- GSM5114189 P15216_222_ko_Naive
- GSM5114190 P15216_223_ko_D7
- GSM5114191 P15216_224_ki_Naive
- GSM5114192 P15216_225_wt_D7
- GSM7109644 Th0 WT2 Th0 WT
- GSM7109645 Th1 WT3 Th1 WT
- GSM7109646 Treg KO1 Treg KO
- GSM7109647 Th1 WT4 Th1 WT
- GSM7109648 Treg KI5 Treg KI
- GSM7109649 Th1 KO4 Th1 KO
- GSM7109650 Treg WT1 Treg WT
- GSM7109651 Th0 KO3 Th0 KO
- GSM7109652 Th0 KI5 Th0 KI
- GSM7109653 Th1 KI2 Th1 KI
- GSM7109654 Treg K05
- GSM7109655 Th0 WT5 Th0 WT
- GSM7109656 Treg WT4 Treg WT
- GSM7109657 Treg KI1 Treg KI
- GSM7109658 Th1 KI5 Th1 KI
+ 29 more — browse all 69 samples with per-sample file links →
- GSE227844 MicroRNA-150 controls experimental autoimmune encephalomyelitis by regulating CD4 T cell differentiation and function [RNA-seq II] 44 samples shares cd4, encephalomyelitis, microrna-150, experimental, autoimmune, regulating, controls
- GSE287323 Transcriptomic profiling of oligodendrocytes, astrocytes, and microglia in an experimental autoimmune encephalomyelitis (EAE) model of demyelination 19 samples shares encephalomyelitis, experimental, autoimmune
- GSE326335 Bulk RNA Sequencing of Chimera-Derived Monocyte-Derived Macrophages Targeted for Mitochondrial ROS During Peak Experimental Autoimmune Encephalomyelitis 14 samples shares encephalomyelitis, experimental, autoimmune
- GSE324711 An adaptive cellular source of IL-17A and IL-17F is critical for the induction of experimental autoimmune encephalomyelitis I 12 samples shares encephalomyelitis, experimental, autoimmune
- GSE262540 Myelin oligodendrocyte glycoprotein reactive Th17 cells drive Janus Kinase 1 dependent transcriptional reprogramming in astrocytes and alter cell surface cytokine receptor profiles during experimental autoimmune encephalomyelitis. 12 samples shares encephalomyelitis, experimental, autoimmune
- GSE287324 Transcriptomic analysis of spinal cord in day 35 experimental autoimmune encephalomyelitis (EAE) model 10 samples shares encephalomyelitis, experimental, autoimmune
- GSE298934 Activation of M3 muscarinic ameliorates experimental autoimmune encephalomyelitis by restoring microglial quiescence 9 samples shares encephalomyelitis, experimental, autoimmune
- GSE289821 A pathogenic CD4 T cell phenotype in experimental uveitis shares common features with other immune mediated inflammatory diseases [EAU] 24 samples shares cd4, experimental
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.