A multivalent mRNA vaccine elicits robust immune responses and confers protection in a murine model of monkeypox virus infection
Single-cell RNA-seq · mouse · 18 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A multivalent mRNA vaccine elicits robust immune responses and confers protection in a murine model of monkeypox virus infectionNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276667_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1156919 and SRA study SRP531335. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8503862 scRNA-seq of mice_1 immunized with AALI
- GSM8503863 scRNA-seq of mice_2 immunized with AALI
- GSM8503864 scRNA-seq of mice_3 immunized with AALI
- GSM8503865 scRNA-seq of mice_1 immunized with LNP
- GSM8503866 scRNA-seq of mice_2 immunized with LNP
- GSM8503867 scRNA-seq of mice_3 immunized with LNP
- GSM8503868 TCR of mice_1 immunized with AALI
- GSM8503869 TCR of mice_2 immunized with AALI
- GSM8503870 TCR of mice_3 immunized with AALI
- GSM8503871 TCR of mice_1 immunized with LNP
- GSM8503872 TCR of mice_2 immunized with LNP
- GSM8503873 TCR of mice_3 immunized with LNP
- GSM8503874 BCR of mice_1 immunized with AALI
- GSM8503875 BCR of mice_2 immunized with AALI
- GSM8503876 BCR of mice_3 immunized with AALI
- GSM8503877 BCR of mice_1 immunized with LNP
- GSM8503878 BCR of mice_2 immunized with LNP
- GSM8503879 BCR of mice_3 immunized with LNP
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- GSE240064 Comparison of unmodified and modified mRNA platforms for Andes virus mRNA vaccine in rodent models 32 samples shares vaccine, virus
- GSE278132 Lung structural cell dynamics are altered by influenza virus infection experience leading to rapid immune protection following viral re-challenge 35 samples shares protection, virus
- GSE255778 Glycan adjuvantation expands the breadth and duration of protection of a mRNA-based vaccine 30 samples shares protection, vaccine
- GSE296072 Atrophin-1 Antisense Oligonucleotide Provides Robust Protection from Pathology in a Fully Humanized DRPLA Model 30 samples shares protection, robust
- GSE279372 Lipid nanoparticles as adjuvant of Norovirus VLP vaccine augment cellular and humoral immune responses in a TLR 9- and type I IFN-dependent pathway 28 samples shares vaccine, virus
- GSE255795 Broad spectrum efficacy of BDGR-164 against neurotropic alphaviruses and correlates of protection 28 samples shares protection, virus
- GSE297741 ILC1 quiescence confers protection against MCMV infections during undernutrition 24 samples shares protection, confers
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.