← BioTransfer GEO Dataset Finder
GEO series

Effect of depletion of PARP2 on gene expression in 3 month-old pancreas from Ela-myc mice

GSE277055 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/04 Platform GPL17021
Summary
Pancreatic cancer represents one of the most lethal tumours, characterised by an immunosuppressive microenvironment and a lack of cytotoxic immune cell infiltrates, which confers resistance to immunotherapy. Here, we demonstrate that the deletion of Poly(ADP-ribose)polymerase 2 (PARP2) delays tumour progression in c-Myc-driven and KRas-driven mouse models of pancreatic cancer. Transcriptomic analysis revealed that the absence of PARP2 induces an enrichment of pathways associated with anti-tumor immune responses and genomic instability. Analysis of tumour-infiltrating immune cells within the tumor microenvironment showed that PARP2 deletion leads to an increase in effector CD4 and CD8 T cells as well as natural killer (NK) cells, accompanied by a significant reduction in pro-tumor regulatory T (Treg) cells and M2 macrophages. Collectively, our data support that selective PARP2 inhibition is a promising therapeutic strategy for pancreatic cancer by boosting anti-tumor immune response, thereby opening new avenues for combating this recalcitrant neoplasia.
Published in
PARP2 deficiency impairs pancreatic cancer progression by promoting genomic instability and antitumor immunity
Martínez-Bosch N, Manero-Rupérez N, Vázquez-Bellón N et al. · Science advances 2026 · PMID 42102213 · doi:10.1126/sciadv.adu8849
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE277055_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1160298 and SRA study SRP532352. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.