GEO series
Investigate the effect of depletion of Mettl14 or Ythdf2 on RNA stability in primary cultured cortical neurons
GSE277231
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2026/01/01
GPL24247
Summary
Across the transcriptome, m6A-modified transcripts showed increased relative stability in the Mettl14 cKO condition , and the number of m6A sites affected the stability. The stability of transcripts with m6A only in the CDS changed slightly less, while the stability of transcripts with m6A only in the 3' UTR or with m6A in both regions increased more significantly, suggesting that m6A in the 3' UTR has a more pronounced effect on mRNA stability. Unexpectedly, m6A-modified transcripts showed only a slight stability change in the DF2 cKO condition.
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