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Genetic Recording of Transient Endothelial Activation in Distinct Alveolar Capillary Cells during Pulmonary Fibrosis

GSE277471 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/09/18 Platform GPL28330
Summary
Endothelial to mesenchymal transition (EndoMT) is essential for embryonic development. However, the contribution of ECs to fibroblasts through EndoMT remains highly controversial in adult pathological conditions. Here, our dual-recombinase genetic system precisely captured extensive mesenchymal gene activation events of alveolar capillary cells in chronic TAC-induced pulmonary hypertension and fibrosis. Moreover, this type of endothelial activation was specifically observed in Plvap+ gCap, but not CAR4+ aCap capillary cells. In addition, our genetic tool confirmed the contribution of resident fibroblasts to pulmonary fibrosis. Unraveling the process of endothelial activation provides novel insights into potential therapeutic strategies targeting heart failure-induced pulmonary fibrosis.
Published in
Genetic recording of transient endothelial activation in distinct alveolar capillary cells during pulmonary fibrosis
Li H, Zhang S, Huang X et al. · Cell discovery 2024 · PMID 39622809 · doi:10.1038/s41421-024-00745-1
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Also filed as BioProject PRJNA1162489 and SRA study SRP533359. Searching any of these in the dataset finder brings you back here.

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