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ROS-Responsive Nanoparticles for Bioimaging and Treating Acute Lung Injury by Improving the Homeostasis of Alveolar Macrophages

GSE277635 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/09/23 Platform GPL28457
Summary
To reveal the molecular biological mechanism of RCMNs in the treatment of acute lung injury, MH-S Cells were stimulated by LPS and treated with RCMNs followed by RNA-seq transcriptome analysis.Functional enrichment analysis of the genes that exhibited significant differential expression following RCMNs treatment revealed their primary involvement in several key biological processes, including mitochondrial respiratory chain complex IV assembly, oxidative phosphorylation, and mitochondrial respiratory chain complex I assembly. These findings suggest that RCMNs exert their therapeutic effects by modulating the expression of genes critical to mitochondrial function and energy metabolism. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis has revealed that RCMs primarily exert their biological functions by modulating several key signaling pathways, including the Calcium signaling pathway, TNF signaling pathway, and Toll-like receptor signaling pathway.
Published in
ROS-responsive nanoparticles for bioimaging and treating acute lung injury by releasing dexamethasone and improving alveolar macrophage homeostasis
Fan W, Tang Y, Liu Y et al. · Journal of nanobiotechnology 2024 · PMID 39578796 · doi:10.1186/s12951-024-03015-0
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Also filed as BioProject PRJNA1163100 and SRA study SRP533795. Searching any of these in the dataset finder brings you back here.

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