A systems pharmacology study of cordycepin demonstrates it blocks growth factor signal transduction
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Cordycepin generally inhibits growth factor signal transduction in a systems pharmacology studyFEBS letters · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277825_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1164276 and SRA study SRP534249. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8532248 HEK293, Cordycepin EGF AMPK KO rep 2 HEK293, Cordycepin EGF …
- GSM8532249 HEK293, Cordycepin EGF AMPK KO rep 3 HEK293, Cordycepin EGF …
- GSM8532250 HEK293, Cordycepin EGF WT rep 2 HEK293, Cordycepin EGF …
- GSM8532251 HEK293, Cordycepin EGF WT rep 3 HEK293, Cordycepin EGF …
- GSM8532252 HEK293, DMSO AMPK KO rep 2 HEK293, DMSO AMPK KO
- GSM8532253 HEK293, DMSO AMPK KO rep 3 HEK293, DMSO AMPK KO
- GSM8532254 HEK293, DMSO EGF AMPK KO rep 2 HEK293, DMSO EGF AMPK KO
- GSM8532255 HEK293, DMSO EGF AMPK KO rep 3 HEK293, DMSO EGF AMPK KO
- GSM8532256 HEK293, DMSO EGF WT rep 2 HEK293, DMSO EGF WT
- GSM8532257 HEK293, DMSO EGF WT rep 3 HEK293, DMSO EGF WT
- GSM8532258 HEK293, DMSO WT rep 2 HEK293, DMSO WT
- GSM8532259 HEK293, DMSO WT rep 3 HEK293, DMSO WT
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.