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PP2A attenuates thoracic aneurysm and dissection in mouse models of Marfan syndrome [RNA-seq]

GSE278185 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/03/26 Platform GPL21103
Summary
Recent studies show that hyperactivation of mTOR signaling plays a causal role in the development of thoracic aortic aneurysm (TAA) and dissection (AAD). Modulation of Protein phosphatase 2A (PP2A) activity has been shown to be of significant therapeutic value. In light of the effects that PP2A can exert on mTOR pathway, we hypothesized that PP2A activation by small molecule activators of PP2A (SMAPs) could mitigate AA progression in Marfan Syndrome (MFS).
Published in
PP2A Attenuates Thoracic Aneurysm and Dissection in Mouse Models of Marfan Syndrome
Zhou X, Xu Q, Hu X et al. · Hypertension (Dallas, Tex. : 1979) 2025 · PMID 39878024 · doi:10.1161/HYPERTENSIONAHA.124.23494
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Also filed as BioProject PRJNA1165827 and SRA study SRP535136. Searching any of these in the dataset finder brings you back here.

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