Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × WT_Female_Day0 vs 4 × WT_Female_Day2 vs 4 × KO_Female_Day0 vs 4 × KO_Female_Day2Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2Journal of immunology (Baltimore, Md. : 1950) · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE278413_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1167203 and SRA study SRP535710. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8546089 WT_Female_Day0_1 WT_Female_Day0
- GSM8546090 WT_Female_Day0_2 WT_Female_Day0
- GSM8546091 WT_Female_Day2_1 WT_Female_Day2
- GSM8546092 WT_Female_Day2_2 WT_Female_Day2
- GSM8546093 KO_Female_Day0_1 KO_Female_Day0
- GSM8546094 KO_Female_Day0_2 KO_Female_Day0
- GSM8546095 KO_Female_Day2_1 KO_Female_Day2
- GSM8546096 KO_Female_Day2_2 KO_Female_Day2
- GSM8546097 WT_Female_Day0_3 WT_Female_Day0
- GSM8546098 WT_Female_Day0_4 WT_Female_Day0
- GSM8546099 WT_Female_Day2_3 WT_Female_Day2
- GSM8546100 WT_Female_Day2_4 WT_Female_Day2
- GSM8546101 KO_Female_Day0_3 KO_Female_Day0
- GSM8546102 KO_Female_Day0_4 KO_Female_Day0
- GSM8546103 KO_Female_Day2_3 KO_Female_Day2
- GSM8546104 KO_Female_Day2_4 KO_Female_Day2
- GSE240834 Synthetic IL-21 cytokine mimetic promotes T cell function 12 samples shares il-2, cytokine
- GSE250576 ATAC-seq of Satb1 conditional KO in CD4+ naïve T cells reveals epigenetic role of Satb1 in developing Th17 T cells by controlling the accessibility of Il2, thereby inhibiting IL-2 signaling in the initial stages of T cell differentiation. 10 samples shares il-2, controlling
- GSE250205 A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies 32 samples shares il-2, cytokine
- GSE10010 IL-22 plays an indispensable role in early host defense against attaching and effacing (A/E) bacterial pathogens 6 samples shares il-2, early
- GSE290258 Satb1 directs the differentiation of TH17 cells through suppression of IL-2 expression [scMultiom ATAC/RNA-seq] 12 samples shares il-2
- GSE279403 Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22 28 samples shares il-2
- GSE280838 IL-21 Shapes the B Cell Response in a Context-Dependent Manner [RNA-seq 27 samples shares il-2
- GSE282979 IL-2/IL-15 signaling induces NK cell production of FLT3LG which augments anti-PD-1 immunotherapy 24 samples shares il-2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.