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Modulation of infiltrating CD206-positive macrophages restricts progression of pulmonary lymphangioleiomyomatosis (LAM)

GSE278445 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/29 Platform GPL34290
Summary
Lymphangioleiomyomatosis (LAM) is a very rare disease affecting women of childbearing age, either sporadically or in association with tuberous sclerosis complex (TSC). The proliferation of TSC2 null LAM cells in the lung results in cystic destruction, airflow obstruction, respiratory insufficiency and eventually death. In the LAM lung, the tumor immune microenvironment (TME) plays a role in the progression of LAM lesions. Macrophages can be polarized into inflammatory M1 macrophages or protumorigenic immunosuppressive M2 macrophages. Macrophages are an important component of the TME, and we hypothesized that CD206+ M2 macrophages could facilitate LAM progression and represent a potential therapeutic target.
Published in
Modulation of infiltrating CD206(+) macrophages restricts progression of pulmonary lymphangioleiomyomatosis
Liu HJ, Diesler R, Chami J et al. · The European respiratory journal 2025 · PMID 40639874 · doi:10.1183/13993003.00084-2025
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Also filed as BioProject PRJNA1167278 and SRA study SRP535759. Searching any of these in the dataset finder brings you back here.

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