SETD2 contributes to PAF1C interactions with the elongating RNA Pol II and is required for neuronal differentiation [ChIP-Seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 18 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The H3K36me3 methyltransferase SETD2 contributes to PAF1C interactions with RNA Pol II and is required for neuronal differentiationThe EMBO journal · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE278956_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1169824 and SRA study SRP536990. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8558830 H3K4me3_KO
- GSM8558831 H3K4me3_WT
- GSM8558832 H3K27me3_KO
- GSM8558833 H3K27me3_WT
- GSM8558834 H3K36me3_KO
- GSM8558835 H3K36me3_WT
- GSM8558836 H4panAc_KO r1 H4panAc_KO
- GSM8558837 H4panAc_KO r2 H4panAc_KO
- GSM8558838 H4panAc_WT r1 H4panAc_WT
- GSM8558839 H4panAc_WT r2 H4panAc_WT
- GSM8558840 Pol2_KO r1 Pol2_KO
- GSM8558841 Pol2_KO r2 Pol2_KO
- GSM8558842 Pol2_WT r1 Pol2_WT
- GSM8558843 Pol2_WT r2 Pol2_WT
- GSM8558844 Pol2S2P_KO r1 Pol2S2P_KO
- GSM8558845 Pol2S2P_KO r2 Pol2S2P_KO
- GSM8558846 Pol2S2P_WT r1 Pol2S2P_WT
- GSM8558847 Pol2S2P_WT r2 Pol2S2P_WT
- GSE262390 Setd2 overexpression rescues bivalent gene expression during SCNT-mediated ZGA by enhancing H3K36me3 at gene bodies and excluding H3K27me3 from promoters [ChIP-seq] 79 samples shares setd2, chip-seq
- GSE287375 CTCF-RNA interactions orchestrate cell-specific chromatin loop organization [ChIP-seq] 54 samples shares interactions, chip-seq
- GSE288455 Unraveling the cohesin-chromatin interface: identifying protein interactions that modulate chromosome structure and function [ChIP-Seq] 22 samples shares interactions, chip-seq
- GSE315062 Smad4-p65 interactions drive BMP-mediated protection against inflammatory cell death [ChIP-Seq] 10 samples shares interactions, chip-seq
- GSE243566 Systematic perturbations of SETD2, NSD1, NSD2, NSD3 and ASH1L reveal their distinct contributions to H3K36 methylation 125 samples shares setd2
- GSE300743 RNA expression of Kras;Setd2 versus Kras mouse lung neoplastic cells 11 samples shares setd2
- GSE304211 H4K16ac contributes to chromatin compartment reorganization during mitotic and meiotic transitions [CUTnTAG] 128 samples shares contributes
- GSE299933 The sleep–wake history contributes to rhythmic BMAL1 chromatin binding in the cerebral cortex but not in the liver 95 samples shares contributes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.