GEO series
Crotonate-activated histone H3K14 crotonylation enhances intestinal regeneration after injury [ChIP-seq]
GSE278970
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
16 samples
2025/08/13
GPL17021
Summary
The intestinal epithelium undergoes rapid turnover driven by Lgr5+ intestinal stem cells (ISCs) at the crypt base, and can recover despite ISC loss during damage. However, the role of epigenetic modifications in regulating this regeneration remains unclear. In this study, we report that H3K14 crotonylation (H3K14cr), a vital histone modification mediated by the acyltransferase HBO1, is essential for intestinal regeneration. HBO1 ablation in the intestinal epithelium exacerbates dextran sulfate sodium (DSS)-induced colitis.
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Paper (PMID 41038843) ↗
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