GEO series
Transcriptome of adult hearts with cardiomyocyte-specific deficiency of Aars2
GSE279007
Mus musculus
Expression profiling by high throughput sequencing
20 samples
2026/02/20
GPL30172GPL21103
Summary
We generated cardiomyocyte-specific Aars2 knockout mice using Myh6-Cre, and observed progressive cardiac function decline starting at postnatal day (P) 28, with severe chamber dilation, and phenotypes reminance of mitochondrial cardiomyopathy. All homozygous mutant mice died before reaching P70. We sought to identify the transcriptome changes by Aars2-deficiency at P14 and P21 in adult, prior to the onset of the cardiomyopathy.
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Paper (PMID 42010330) ↗
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