single-nucleus transcriptomic analysis of cortical tissue from control and Dot1l HET 10 week old mice.
Single-nucleus RNA-seq · mouse · 2 samples
- What it is
- Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue).
- Organism
- Mus musculus (mouse)
- Samples
- 2 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Loss of DOT1L disrupts neuronal transcription and leads to a neurodevelopmental disorderBrain : a journal of neurology · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279120_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1170913 and SRA study SRP537630. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 2 more — browse all 2 samples with per-sample file links →
- GSE292609 ChIP-seq analysis of control and DOT1L HET cortical nuclei. 18 samples shares dot1l, het, cortical, control
- GSE305266 The cortical microenvironment drives early immune organization and controls early osteoclastogenesis in bone healing 90 samples shares cortical, control
- GSE294832 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part10] 1000 samples shares het
- GSE294911 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part14] 1000 samples shares het
- GSE294535 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice[part5] 1000 samples shares het
- GSE294849 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part13] 1000 samples shares het
- GSE294826 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part9] 1000 samples shares het
- GSE294983 Modular neuroinflammatory network discovery from large-scale phenotypic screening in genetically heterogeneous mice [part20] 1000 samples shares het
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.