Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function
RNA-seq (gene expression) · human · 156 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 156 samples: 73 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279322_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1171846 and SRA study SRP492414. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 146 samples.
How we read this: 73 replicated groups read from 156 sample titles; they account for 146 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8118692 300.12_NWBB7_4w 300.12_NWBB7_4w
- GSM8118693 300.12_NWBB7_6w 300.12_NWBB7_6w
- GSM8118694 300.12_NWBB7_8w 300.12_NWBB7_8w
- GSM8118695 300.12_NWBB7_Astro 300.12_NWBB7_Astro
- GSM8118696 300.12_NW1C7_4w 300.12_NW1C7_4w
- GSM8118697 300.12_NW1C7_6w 300.12_NW1C7_6w
- GSM8118698 300.12_NW1C7_8w 300.12_NW1C7_8w
- GSM8118699 300.12_NW1C7_Astro 300.12_NW1C7_Astro
- GSM8118700 300.12-NW1B10_4w 300.12-NW1B10_4w
- GSM8118701 300.12-NW1B10_6w 300.12-NW1B10_6w
- GSM8118702 300.12-NW1B10_8w 300.12-NW1B10_8w
- GSM8118703 300.12-NW1B10_Astro 300.12-NW1B10_Astro
- GSM8118704 300.12_NH1E7_4w 300.12_NH1E7_4w
- GSM8118705 300.12_NH1E7_6w 300.12_NH1E7_6w
- GSM8118706 300.12_NH1E7_8w 300.12_NH1E7_8w
- GSM8118707 300.12_NH1E7_Astro 300.12_NH1E7_Astro
- GSM8118708 300.12_HCB8_4w 300.12_HCB8_4w
- GSM8118709 300.12_HCB8_6w 300.12_HCB8_6w
- GSM8118710 300.12_HCB8_8w 300.12_HCB8_8w
- GSM8118711 300.12_HBE10_4w 300.12_HBE10_4w
- GSM8118712 300.12_HBE10_6w 300.12_HBE10_6w
- GSM8118713 300.12_HBE10_8w 300.12_HBE10_8w
- GSM8118714 300.12_HBE10_Astro 300.12_HBE10_Astro
- GSM8118715 300.12_HAE11_4w 300.12_HAE11_4w
- GSM8118716 300.12_HAE11_6w 300.12_HAE11_6w
- GSM8118717 300.12_HAE11_8w 300.12_HAE11_8w
- GSM8118718 300.12_HAE11_Astro 300.12_HAE11_Astro
- GSM8118719 75.11_IW1G8_4w 75.11_IW1G8_4w
- GSM8118720 75.11_IW1G8_6w 75.11_IW1G8_6w
- GSM8118721 75.11_IW1G8_8w 75.11_IW1G8_8w
- GSM8118722 75.11_IW1G8_Astro
- GSM8118723 75.11_IW1F3_4w 75.11_IW1F3_4w
- GSM8118724 75.11_IW1F3_6w 75.11_IW1F3_6w
- GSM8118725 75.11_IW1F3_8w 75.11_IW1F3_8w
- GSM8118726 75.11_IW1F3_Astro
- GSM8118727 75.11_IW1A12_4w 75.11_IW1A12_4w
- GSM8118728 75.11_IW1A12_6w 75.11_IW1A12_6w
- GSM8118729 75.11_IW1A12_8w 75.11_IW1A12_8w
- GSM8118730 75.11_IW1A12_Astro
- GSM8118734 75.11_IH1A8_4w 75.11_IH1A8_4w
+ 116 more — browse all 156 samples with per-sample file links →
- GSE260517 Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function [bulkRNA-seq] 83 samples shares mapt, s305, exhibiting, astrocytic, resulting, mutation, elevated, neuronal
- GSE279321 Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function [Targeted MAPT ISO-seq] 73 samples shares mapt, s305, exhibiting, astrocytic, resulting, mutation, elevated, neuronal
- GSE324430 Promoter mutagenesis and a massively parallel reporter screen of the MAPT locus identifies cis-regulatory elements and genetic variation effects [RNA-seq] 88 samples shares mapt
- GSE230450 Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons 22 samples shares mapt
- GSE230519 Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons 21 samples shares mapt
- GSE250316 Splicing factor PTBP1 promotes hepatocarcinogenesis via oncogenic splice-switching of MAPT 6 samples shares mapt
- GSE325670 Promoter mutagenesis and a massively parallel reporter screen of the MAPT locus identifies cis-regulatory elements and genetic variation effects 140 samples shares mapt
- GSE230520 Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons 61 samples shares mapt
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.