GEO series
BGN promotes epithelial migration in mammary gland development and breast cancer metastasis through activation of WNT signaling
GSE279436
Mus musculus
Expression profiling by high throughput sequencing
10 samples
2024/10/19
GPL24247
Summary
This study investigates the role of Biglycan (BGN) in promoting epithelial migration during mammary gland development and breast cancer metastasis. Using in vitro and in vivo models, including a 3D organoid migration assay and single-cell RNA sequencing, we demonstrate that BGN enhances the interaction between WNT3A and FZD6, activating the WNT signaling pathway. This activation promotes epithelial cell migration and breast cancer metastasis. The findings provide new insights into breast cancer metastasis mechanisms and identify BGN as a potential therapeutic target.
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