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G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer [ATAC-seq]

GSE279495 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2025/06/06 Platform GPL24676
Summary
Chromatin accessibilty is a key regulator of gene expression. In this study we aim to map accessible chromatin regions in both chemotherapy sensitive (PEO1) and chemotherapy resistant (PEO4) ovarian cancer cell lines, to intersect with RNA-seq data to see how chromatin architecture changes and impacts gene expression between the two cell lines.
Published in
G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer cells
Robinson J, Flint G, Garner I et al. · Genome biology 2025 · PMID 40646632 · doi:10.1186/s13059-025-03654-y
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Also filed as BioProject PRJNA1173148 and SRA study SRP538680. Searching any of these in the dataset finder brings you back here.

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