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Analysis of gene expression levels in ovaries of wild-type and ABCG5/G8 knockout mice

GSE279573 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2024/10/25 Platform GPL17021
Summary
A heterodimer of ATP-binding cassette transporters G5 and G8 (ABCG5/G8) functions as a lipid exporter in the intestine. Homozygous ABCG5/G8 knockout female mice exhibit infertility under normal chow diet conditions due to impaired folliculogenesis and poor egg quality. Interestingly, this infertility was restored by changing the diet from a chow diet (CD) to a vegetable oil-free diet (VOFD). To elucidate mechanisms underlying the diet-induced infertiility in ABCG5/G8 KO mice, RNA-seq analyses were conducted and found that multiple genes potentially involved in the reproductive system and embryogenesis, in addition to those involved in sterol biosynthesis, were down regulated in the ovaryes from CD-fed infertile KO mice compared to those from fertile CD-fed wild-type mice and VOFD-fed KO mice.
Published in
Dietary phytosterols induce infertility in female mice via epigenomic modulations
Yamanashi Y, Komine T, Hirota Y et al. · Communications biology 2024 · PMID 39562830 · doi:10.1038/s42003-024-07233-y
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Also filed as BioProject PRJNA1173534 and SRA study SRP538874. Searching any of these in the dataset finder brings you back here.

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